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1

The Aromatase Excess Syndrome Is Associated with Feminization of Both Sexes and Autosomal Dominant Transmission of Aberrant P450 Aromatase Gene Transcription 1

Stratakis, Constantine A., Vottero, Alessandra, Brodie, Angela, Kirschner, Lawrence S., DeAtkine, David, Lu, Qing, Yue, Wei, Mitsiades, Constantine S., Flor, Armando W., Chrousos, George P.

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

1998

Langue:

english

Fichier:

PDF, 1.90 MB

english, 1998

2

Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion

Russart, Kathryn L.G., Huk, Danielle, Nelson, Randy J., Kirschner, Lawrence S.

Journal:

Hormones and Behavior

Année:

2018

Langue:

english

Fichier:

PDF, 667 KB

english, 2018

3

Carney complex: Diagnosis and management of the complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas

Stratakis, Constantine A., Kirschner, Lawrence S., Carney, J. Aidan

Journal:

American Journal of Medical Genetics

Année:

1998

Langue:

english

Fichier:

PDF, 36 KB

english, 1998

4

Development of a pituitary-specific cre line targeted to the Pit-1 lineage

Zhirong Yin, Lisa Williams-Simons, Lisa Rawahneh, Sylvia Asa, Lawrence S. Kirschner

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 347 KB

english, 2008

5

Regulatory subunit type I-α of protein kinase A (PRKAR1A): A tumor-suppressor gene for sporadic thyroid cancer

Fabiano Sandrini, Ludmila Matyakhina, Nicholas J. Sarlis, Lawrence S. Kirschner, Constantine Farmakidis, Oliver Gimm, Constantine A. Stratakis

Journal:

Genes, Chromosomes and Cancer

Année:

2002

Langue:

english

Fichier:

PDF, 13.02 MB

english, 2002

6

Sequence analysis of the PRKAR1A gene in sporadic somatotroph and other pituitary tumours

Gregory A. Kaltsas, Blerina Kola, Ninetta Borboli, Damian G. Morris, Maria Gueorguiev, Frankie M. Swords, Sándor Czirják, Lawrence S. Kirschner, Constantine A. Stratakis, Márta Korbonits, Ashley B. Gr

Journal:

Clinical Endocrinology

Année:

2002

Langue:

english

Fichier:

PDF, 145 KB

english, 2002

7

Targeted Therapies for Adrenocortical Carcinoma: IGF and Beyond

Michael J. Demeure, Kimberly J. Bussey, Lawrence S. Kirschner

Journal:

Hormones and Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 214 KB

english, 2011

8

Signaling Pathways in Adrenocortical Cancer

LAWRENCE S. KIRSCHNER

Journal:

Annals of the New York Academy of Sciences

Année:

2002

Langue:

english

Fichier:

PDF, 377 KB

english, 2002

9

10.1038/79238

Stratakis, Constantine A., Kirschner, Lawrence S., Carney, J. Aidan, Pack, Svetlana D., Taymans, Susan E., Giatzakis, Christoforos, Cho, Yee Sook, Cho-Chung, Yoon S.

Journal:

Nature Genetics

Année:

2000

Langue:

english

Fichier:

PDF, 268 KB

english, 2000

10

Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1

Nadella, Kiran S, Saji, Motoyasu, Jacob, Naduparambil K, Pavel, Emilia, Ringel, Matthew D, Kirschner, Lawrence S

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 188 KB

english, 2009

11

Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1

Nadella, Kiran S, Saji, Motoyasu, Jacob, Naduparambil K, Pavel, Emilia, Ringel, Matthew D, Kirschner, Lawrence S

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 875 KB

english, 2009

12

Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators

Libutti, Steven K, Stratakis, Constantine A, Bourdeau, Isabelle, Antonini, Sonir R, Lacroix, André, Kirschner, Lawrence S, Matyakhina, Ludmila, Lorang, Dominique

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 195 KB

english, 2004

13

The Carney complex Gene PRKAR1A Plays an Essential Role in Cardiac Development and Myxomagenesis

Zhirong Yin, Lawrence S. Kirschner

Journal:

Trends in Cardiovascular Medicine

Année:

2009

Langue:

english

Fichier:

PDF, 209 KB

english, 2009

14

Cloning and Characterization of a Novel Orphan G-Protein-Coupled Receptor Localized to Human Chromosome 2p16

Emma E. Tarttelin, Lawrence S. Kirschner, James Bellingham, Judit Baffi, Susan E. Taymans, Kevin Gregory-Evans, Karl Csaky, Constantine A. Stratakis, Cheryl Y. Gregory-Evans

Journal:

Biochemical and Biophysical Research Communications

Année:

1999

Langue:

english

Fichier:

PDF, 310 KB

english, 1999

15

Structure of the Human Ubiquitin Fusion Gene Uba80 (RPS27a) and One of Its Pseudogenes

Lawrence S. Kirschner, Constantine A. Stratakis

Journal:

Biochemical and Biophysical Research Communications

Année:

2000

Langue:

english

Fichier:

PDF, 134 KB

english, 2000

16

Radiation Hybrid Mapping of Chromosomal Region 2p15–p16: Integration of Expressed and Polymorphic Sequences Maps at the Carney Complex (CNC) and Doyne Honeycomb Retinal Dystrophy (DHRD) Loci

Susan E. Taymans, Lawrence S. Kirschner, Christophoros Giatzakis, Constantine A. Stratakis

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 190 KB

english, 1999

17

Genomic Mapping of Chromosomal Region 2p15–p21 (D2S378–D2S391): Integration of Genemap'98 within a Framework of Yeast and Bacterial Artificial Chromosomes

Lawrence S. Kirschner, Susan E. Taymans, Svetlana Pack, Evgenia Pak, Brian L. Pike, Settara C. Chandrasekharappa, Zhengping Zhuang, Constantine A. Stratakis

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 205 KB

english, 1999

18

Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells

Lawrence S. Kirschner, Lee M. Greenberger, Stephen I.-Hong Hsu, Chia-Ping Huang Yang, Dalia Cohen, Richard L. Piekarz, Gonzalo Castillo, Edward Kyu-Ho Han, Lijia Yu, Susan Band Horwitz

Journal:

Biochemical Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1992

19

Mouse models of endocrine tumours

Georgette N. Jones, Parmeet K. Manchanda, Daphne R. Pringle, Mei Zhang, Lawrence S. Kirschner

Journal:

Best Practice & Research Clinical Endocrinology & Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 155 KB

english, 2010

20

Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion

Woo-Jin Song, Madhav Seshadri, Uzair Ashraf, Thembi Mdluli, Prosenjit Mondal, Meg Keil, Monalisa Azevedo, Lawrence S. Kirschner, Constantine A. Stratakis, Mehboob A. Hussain

Journal:

Cell Metabolism

Année:

2011

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2011

21

PRKAR1A and the evolution of pituitary tumors

Lawrence S. Kirschner

Journal:

Molecular and Cellular Endocrinology

Année:

2010

Langue:

english

Fichier:

PDF, 443 KB

english, 2010

22

The next generation of therapies for adrenocortical cancers

Lawrence S. Kirschner

Journal:

Trends in Endocrinology & Metabolism

Année:

2012

Langue:

english

Fichier:

PDF, 349 KB

english, 2012

23

P450arom gene expression in peripheral blood lymphocytes: Identification of a cryptic splice site for exon-1 afterEpstein–Barr virus transformation

Alessandra Vottero, Lawrence S Kirschner, Wei Yue, Angela Brodie, Constantine A Stratakis

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 184 KB

english, 1998

24

Adrenal disease in childhood: caught at an awkward age

Lawrence S Kirschner

Journal:

Trends in Endocrinology & Metabolism

Année:

2002

Langue:

english

Fichier:

PDF, 28 KB

english, 2002

25

Molecular Analysis of the Cyclic AMP-Dependent Protein Kinase A (PKA) Regulatory Subunit 1A (PRKAR1A) Gene in Patients with Carney Complex and Primary Pigmented Nodular Adrenocortical Disease (PPNAD) Reveals Novel Mutations and Clues For Pathophysiology: Augmented PKA Signaling is Associated with Adrenal Tumorigenesis in PPNAD

Lionel Groussin, Lawrence S. Kirschner, Caroline Vincent-Dejean, Karine Perlemoine, Eric Jullian, Brigitte Delemer, Sabina Zacharieva, Duarte Pignatelli, J. Aidan Carney, Jean Pierre Luton, Xavier Ber

Journal:

The American Journal of Human Genetics

Année:

2002

Langue:

english

Fichier:

PDF, 913 KB

english, 2002

26

Quantitative electron microscopy of microtubule assembly in vitro

Marc W. Kirschner, Lawrence S. Honig, Robley C. Williams

Journal:

Journal of Molecular Biology

Année:

1975

Langue:

english

Fichier:

PDF, 7.83 MB

english, 1975

27

Tissue-Specific Ablation of Prkar1a Causes Schwannomas by Suppressing Neurofibromatosis Protein Production

Jones, Georgette N., Tep, Chhavy, Towns, William H., Mihai, Georgeta, Tonks, Ian D., Kay, Graham F., Schmalbrock, Petra M., Stemmer-Rachamimov, Anat O., Yoon, Sung Ok, Kirschner, Lawrence S.

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2008

28

Myelin Structural Integrity in a Model for Human Early-Onset CMT1B

Crowther, Michelle, Shy, Brian, Luoma, Adrienne M., Wrabetz, Lawrence, Shy, Michael E., Kirschner, Daniel A.

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 40 KB

english, 2009

29

Synthetic Peptide Homologous to β Protein from Alzheimer Disease Forms Amyloid-Like Fibrils in vitro

Daniel A. Kirschner, Hideyo Inouye, Lawrence K. Duffy, Alison Sinclair, Marcia Lind and Dennis J. Selkoe

Journal:

Proceedings of the National Academy of Sciences

Année:

1987

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1987

30

A Mouse Model for Carney Complex

Griffin, Kurt J., Kirschner, Lawrence S., Matyakhina, Ludmila, Stergiopoulos, Sotirios, Robinson‐White, Audrey, Weinberg, Frank, Meoli, Elise, Bornstein, Stefan R., Stratakis, Constantine A.

Journal:

Endocrine Research

Année:

2004

Langue:

english

Fichier:

PDF, 315 KB

english, 2004

31

characterization of the adrenal gland pathology of carney complex, and molecular genetics of the disease.

Kirschner, Lawrence S., Taymans, Susan E., Stratakis, Constantine A.

Journal:

Endocrine Research

Année:

1998

Langue:

english

Fichier:

PDF, 145 KB

english, 1998

32

A video-based spin-polarized LEED data-acquisition system

Giergiel, J., Hopster, H., Lawrence, J. M., Hemminger, J. C., Kirschner, J.

Journal:

Review of Scientific Instruments

Année:

1995

Langue:

english

Fichier:

PDF, 1002 KB

english, 1995

33

Adipose S14 mRNA is Abnormally Regulated in Obese Subjects

KIRSCHNER, LAWRENCE S., MARIASH, CARY N.

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 892 KB

english, 1999

34

Amplification of the Murine mdr 2 Gene and a Reconsideration of the Structure of the Murine mdr Gene Locus

KIRSCHNER, LAWRENCE S.

Journal:

DNA and Cell Biology

Année:

1995

Langue:

english

Fichier:

PDF, 14.75 MB

english, 1995

35

Inhibition of IGF-1R in adrenocortical carcinoma

Kirschner, Lawrence S

Journal:

The Lancet Oncology

Année:

2015

Langue:

english

Fichier:

PDF, 151 KB

english, 2015

36

Emerging Treatment Strategies for Adrenocortical Carcinoma: A New Hope

Kirschner, Lawrence S.

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2006

Langue:

english

Fichier:

PDF, 99 KB

english, 2006

37

Knockdown of PRKAR1A , the Gene Responsible for Carney Complex, Interferes With Differentiation in Osteoblastic Cells

Zhang, Mei, Manchanda, Parmeet K., Wu, Dayong, Wang, Qianben, Kirschner, Lawrence S.

Journal:

Molecular Endocrinology

Année:

2014

Langue:

english

Fichier:

PDF, 2.21 MB

english, 2014

38

Fully Moderated T-statistic for Small Sample Size Gene Expression Arrays

Yu, Lianbo, Gulati, Parul, Fernandez, Soledad, Pennell, Michael, Kirschner, Lawrence, Jarjoura, David

Journal:

Statistical Applications in Genetics and Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2011

39

Mouse models of thyroid cancer: A 2015 update

Kirschner, Lawrence S., Qamri, Zahida, Kari, Suresh, Ashtekar, Amruta

Journal:

Molecular and Cellular Endocrinology

Année:

2015

Langue:

english

Fichier:

PDF, 457 KB

english, 2015

40

Clinical and Genetic Heterogeneity, Overlap with Other Tumor Syndromes, and Atypical Glucocorticoid Hormone Secretion in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Compared with Other Adrenocortical Tumors

Hsiao, Hui-Pin, Kirschner, Lawrence S., Bourdeau, Isabelle, Keil, Margaret F., Boikos, Sosipatros A., Verma, Somya, Robinson-White, Audrey J., Nesterova, Maria, Lacroix, André, Stratakis, Constantine

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2009

Langue:

english

Fichier:

PDF, 250 KB

english, 2009

41

Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a

Yin, Zhirong, Pringle, Daphne R., Jones, Georgette N., Kelly, Kimberly M., Kirschner, Lawrence S.

Journal:

Molecular Endocrinology

Année:

2011

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2011

42

Spectrum of Mutations of the AAAS Gene in Allgrove Syndrome: Lack of Mutations in Six Kindreds with Isolated Resistance to Corticotropin

Sandrini, Fabiano, Farmakidis, Constantine, Kirschner, Lawrence S., Wu, Shao-Ming, Tullio-Pelet, Anna, Lyonnet, Stanislas, Metzger, Daniel L., Bourdony, Carlos J., Tiosano, Dov, Chan, Wai-Yee, Stratak

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2001

Langue:

english

Fichier:

PDF, 211 KB

english, 2001

43

Pituitary-Specific Knockout of the Carney Complex Gene Prkar1a Leads to Pituitary Tumorigenesis

Yin, Zhirong, Williams-Simons, Lisa, Parlow, A. F., Asa, Sylvia, Kirschner, Lawrence S.

Journal:

Molecular Endocrinology

Année:

2008

Langue:

english

Fichier:

PDF, 664 KB

english, 2008

44

Mutation of Prkar1a Causes Osteoblast Neoplasia Driven by Dysregulation of Protein Kinase A

Pavel, Emilia, Nadella, Kiran, Towns, William H., Kirschner, Lawrence S.

Journal:

Molecular Endocrinology

Année:

2008

Langue:

english

Fichier:

PDF, 612 KB

english, 2008

45

Paradigms for Adrenal Cancer: Think Globally, Act Locally

Kirschner, Lawrence S.

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2006

Langue:

english

Fichier:

PDF, 43 KB

english, 2006

46

Isolated Familial Somatotropinomas: Does the Disease Map to 11q13 or to 2p16?

Stratakis, Constantine A., Kirschner, Lawrence S.

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2000

Langue:

english

Fichier:

PDF, 184 KB

english, 2000

47

Clinical and Molecular Features of the Carney Complex: Diagnostic Criteria and Recommendations for Patient Evaluation

Stratakis, Constantine A., Kirschner, Lawrence S., Carney, J. Aidan

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2001

Langue:

english

Fichier:

PDF, 95 KB

english, 2001

48

Carney Complex, Peutz-Jeghers Syndrome, Cowden Disease, and Bannayan-Zonana Syndrome Share Cutaneous and Endocrine Manifestations, But Not Genetic Loci

Stratakis, Constantine A., Kirschner, Lawrence S., Taymans, Susan E., Tomlinson, Ian P. M., Marsh, Debbie J., Torpy, David J., Giatzakis, Christoforos, Eccles, Diana M., Theaker, Jeffrey, Houlston, Ri

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

1998

Langue:

english

Fichier:

PDF, 319 KB

english, 1998

49

Gaining Traction in the Treatment of Adrenocortical Carcinoma

Kirschner, Lawrence S.

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2013

Langue:

english

Fichier:

PDF, 135 KB

english, 2013

50

Ovarian Lesions in Carney Complex: Clinical Genetics and Possible Predisposition to Malignancy

Stratakis, Constantine A., Papageorgiou, Theocharis, Premkumar, Ahalya, Pack, Svetlana, Kirschner, Lawrence S., Taymans, Susan E., Zhuang, Zhengping, Oelkers, Wolfgang H., Carney, J. Aidan

Journal:

Journal of Clinical Endocrinology & Metabolism

Année:

2000

Langue:

english

Fichier:

PDF, 3.11 MB

english, 2000